SYNTHESIS OF 4-EPI-2-DEOXY-2-H-EQ-N-ACETYLNEURAMINIC ACID AND 2,4-DIDEOXY-2-H-EQ-N-ACETYLNEURAMINIC ACID

摘要

We have continued our work to develop novel analogues of sialic acid [1-4] that may specifically modulate the interaction between endogenous sialic acid and influenza virus haemagglutinin [3,5,6]. Functional groups of sialic acid that have been implicated for this virus-host recongnition are the glycerol side chain, N-acetyl group and the axially oriented carboxylic acid function [3]. In this report we describe the synthesis of two analogues, namely, 4-epi-2-deoxy-2-H-eq-N-acetylneuraminic acid (4-epi-2-d-2-H-eq-Neu5Ac) and 2,4-dideoxy-2-H-eq-N-acetylneuraminic acid (2,4-d(2)-2-H-eq-Neu5Ac). [References: 15]