Inclusion complex formation constants of alpha-, beta-, gamma-, delta-, epsilon-, zeta-, eta- and theta-cyclodextrins determined with capillary zone electrophoresis

摘要

In contrast to the well known small cyclodextrins (CD), cyclomaltohexaose (alpha-CD), cyclomaltoheptaose (beta-CD) and cyclomaltooctaose (gamma-CD), very limited information is available on larger CD and their inclusion complex forming properties. Using capillary electrophoresis, the binding constants of inclusion complexes formed with cyclomaltononaose (delta-CD), cyclomaltodecaose (epsilon-CD), cyclomaltoundecaose (zeta-CD), cyclomaltododecaose (eta-CD) and cyclomaltotridecaose (theta-CD) and various anions were determined and compared to the corresponding binding constants of alpha-, beta- and gamma-CD. All of the large CD were capable to form inclusion complexes. Dependent on the type of guest molecules, delta- and epsilon-CD were the weakest complex formers. The complex forming ability of epsilon, zeta-, eta-, and theta-CD increased with increasing size of the ring structure and theta-CD displayed inclusion complex formation constants comparable to gamma-CD. (C) 1998 Elsevier Science Ltd. All rights reserved. [References: 39]