Successful Treatment of Cutaneous Zygomycosis With Intravenous Amphotericin B Followed by Oral Posaconazole in a Multivisceral Transplant Recipient

摘要

Zygomycosis because of Cunning-hamella bertholletiae is a rare infection caused by ubiquitous spore-forming saprophytic fungi in the order of Muco-rales, class of Zygomycetes (I). Risk factors for zygomycosis include prolonged neutropenia, solid organ transplantation, renal failure, hematologic malignancies, corticosteroid, voriconazole or caspofun-gin use, diabetes mellitus, and skin disruption by trauma or burns (2-4).To date, only seven pediatric cases of C. bertholletiae infections have been reported, of whom five died (5-10) (Table 1). None of the patients had cutaneous infection. Five patients were treated with amphotericin B, of whom two survived and three died. In this report, we describe a case of cutaneous C. bertholletiae infection in a 16-year-old multivisceral transplant recipient.