Anti-Human Leukocyte Antigen Antibodies After Islet Transplantation: What do They Really Mean?

摘要

Human islet allotransplantation is one possible way to achieve insulin independence in type-1 diabetic patients. Current results, emerging from few selected centers worldwide are much more encouraging than in the past. Nevertheless, although the number of insulin-free recipients has significantly increased with modern isolation procedures (including multiple donors) and new immunosuppressive drug associations, the percentage of long-term success is far from that observed after solid pancreatic transplantation (I). As a result of such disappointing results, islet transplantation cannot yet be considered as an alternative therapy to whole pancreatic transplantation#