RE: Severe mental illness at ART initiation is associated with worse retention in care among HIV-infected Ugandan adults by JM Nachega et al. (2013), TMIH 18, pp 53-57

摘要

I read with great interest the recent article by Nachega et al. (2013). Interestingly, one common cause of psychiatric symptoms in HIV patients that is often overlooked is efavirenz therapy. Nearly 13% of patients on efavirenz therapy discontinue the drug secondary to its adverse psychiatric effects (Hasse et al. 2005). Psychiatric symptoms are reported by more than half of all patients on efavirenz therapy. Perez-Molina (2002) have reported a much higher rate of psychiatric symptoms, in almost 73% of HIV patients on efavirenz therapy. CYP2B6-G516T polymorphisms have a significant influence on the clearance of efavirenz.