A strategy to introduce the pH sensitivity to temperature sensitive PNIPAAm hydrogels without weakening the thermosensitivity

摘要

A series of novel pH and thermosensitive hydrogels,comprised of N-sopropylacrylamide(NIPAAm)and N-isopropyl-maleamic acid(NIPMMA)units were designed and fabricated.The resultant P(NIPAAm-co-NIPMMA)hydrogels were characterized and it was found,with the increasing content of NIPMMA,that the pH sensitivity of P(NIPAAm-co-NIPMMA)hydrogel improved,whilst the temperature sensitivity remained almost the same.This unique intelligent character was attributed to the existence of a continuous iso-propylamide sequence in P(NIPAAm-co-NIPMMA)hydrogels.