SOLUTION CONFORMATION AND DYNAMICS OF A TETRASACCHARIDE RELATED TO THE LEWIS(X) ANTIGEN DEDUCED BY H-1 NMR NOESY, ROESY, AND T-ROESY MEASUREMENTS

摘要

The conformational and dynamical features of a Le(X) tetrasaccharide analogue GalNAc(alpha 1-3)Gal(beta 1-4)[Fuc(alpha 1-3)]Glc(beta OMe) 1 have been studied through H-1 NMR relaxation measurements. The results indicate that the different glycosidic linkages of 1 present distinct conformational flexibility in solution. In addition, the use of T-ROESY experiments in conformational analysis of oligosaccharides is explored emphasizing its scope and limitations. (C) 1997 Elsevier Science Ltd. [References: 53]