Stereoselective oxidation metabolism of 20(S)-protopanaxatriol in human liver microsomes and in rats

Wang Wenyan; Ni Yingying; Wang Li; Che Xin; Liu Wanhui; Meng Qingguo

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Stereoselective oxidation metabolism of 20(S)-protopanaxatriol in human liver microsomes and in rats

机译：人肝微粒体和大鼠中20（S）-原托那那三醇的立体选择性氧化代谢

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1. In this study, the oxidative metabolites of 20(S)-protopanaxatriol (PPT) were identified in human liver microsomes (HLMs) and in rats using liquid chromatography-electrospray ionization tandem mass spectrometry.

机译：1.在这项研究中，使用液相色谱-电喷雾串联质谱法在人肝微粒体（HLMs）和大鼠中鉴定了20（S）-异丙氧萘并三醇（PPT）的氧化代谢产物。

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《Xenobiotica: the fate of foreign compounds in biological systems》 |2015年第12期|共11页
作者
Wang Wenyan; Ni Yingying; Wang Li; Che Xin; Liu Wanhui; Meng Qingguo;
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正文语种 eng
中图分类毒物学（毒理学）;
关键词
20(S)-Protopanaxatriol; enzyme kinetics; liver microsomes; metabolite identification; P450 isoforms; stereoselectivity;

机译：20（S）-普萘普生三酚;酶动力学;肝微粒体;代谢产物鉴定;P450亚型;立体选择性;

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1. Stereoselective oxidation metabolism of 20(S)-protopanaxatriol in human liver microsomes and in rats [J] . Wang Wenyan, Ni Yingying, Wang Li, Xenobiotica: the fate of foreign compounds in biological systems . 2015,第1a12期

机译：人肝微粒体和大鼠中20（S）-原托那那三醇的立体选择性氧化代谢
2. Stereoselective metabolism of (±)-praeruptorin A, a calcium channel blocker from Peucedani Radix, in pooled liver microsomes of rats and humans [J] . SongY.L., JingW.H., ZhaoH.Y., Xenobiotica: the fate of foreign compounds in biological systems . 2012,第3期

机译：Peucedani Radix的钙通道阻滞剂（±）-praeruptorin A在大鼠和人的肝微粒体中的立体选择性代谢
3. Oxidation of butadiene monoxide to meso- and (+/-)-diepoxybutane by cDNA-expressed human cytochrome P450s and by mouse, rat, and human liver microsomes: Evidence for preferential hydration of meso-diepoxybutane in rat and human liver microsomes [J] . Krause RJ, Elfarra AA, UNIV WISCONSIN CTR ENVIRONM TOXICOL MADISON WI 53706. Archives of Biochemistry and Biophysics . 1997,第2期

机译：cDNA表达的人细胞色素P450以及小鼠，大鼠和人肝微粒体将一氧化二丁烯氧化为内消旋和（+/-）-双环氧丁烷：在大鼠和人肝微粒体内优先使中消旋二环氧丁烷水合的证据
4. METABOLISM OF 2,2',3,4',5',6-HEXACHLOROBIPHENYL (CB149) BY LIVER MICROSOMES FROM RATS, HAMSTERS, GUINEA PIGS AND HUMANS [C] . Ohta C, Haraguchi K, Kato Y, International symposium on halogenated persistent organic pollutants . 2009

机译：大鼠，仓鼠，几内亚猪和人类肝脏微粒体对2,2'，3,4'，5'，6-六氯联苯（CB149）的代谢
5. System-dependent metabolism of drugs by cytochrome P450: The mechanistic basis for why human liver microsomes are superior to human hepatocytes at metabolizing midazolam but inferior at metabolizing desloratadine [D] . Kazmi, Faraz 2015

机译：细胞色素P450对系统的药物依赖性代谢：为什么人肝微粒体在代谢咪达唑仑时要优于人肝细胞，而在地氯雷他定的代谢时却不如人肝细胞的机理基础
6. In Vitro Metabolism of 20(R)-25-Methoxyl-Dammarane-3 12 20-Triol from Panax notoginseng in Human Monkey Dog Rat and Mouse Liver Microsomes [O] . Xiangrong Zhang, Ji Zhang, Wei Li, -1

机译：来自人参的20（R）-25-甲氧基-Dammarane-3、12、20-三醇在人猴狗大鼠和小鼠肝脏微粒体内的体外代谢
7. Comparison of In Vitro Stereoselective Metabolism of Bupropion in Human, Monkey, Rat, and Mouse Liver Microsomes [O] . Chandrali Bhattacharya, Danielle Kirby, Michael Van Stipdonk, 2018

机译：人，猴，大鼠和小鼠肝微粒体中Bupropion体外立体选择性代谢的比较
8. Effect of Gender on the Rate of Metabolism of Midazolam in Humans Using Liver Microsomes. [R] . Hinkle, K. L. 1997

机译：性别对人类利用肝微粒体对咪达唑仑代谢率的影响。

Stereoselective oxidation metabolism of 20(S)-protopanaxatriol in human liver microsomes and in rats

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