Crosslinking of alginic acid/chitosan matrices using polycarboxylic acids and their utilization for sodium diclofenac release

摘要

Three different ratios of alginic acid/chitosan matrices of ratios 3/1,1/1 and 1/2,respectively,were crosslinked in their dry state using citric acid(CA)/sodium hypophosphite(SHP)at different conditions controlling the crosslinking process such as citric acid concentration,citric acid/sodium hypophosphite molar ratio as well as time and temperature of reaction.Results indicate that such matrices were crosslinked efficiently on curing at 180°C for 9 min in presence of CA/SHP ratio 1 and the citric acid concentration of 0.6 based on the weight of any matrices.The crosslinked matrices were characterized by investigating their swelling properties,FT-IR and thermalgravi-metric analysis.Furthermore,such crosslinked matrices were tested as drug release for sodium diclofenac.