Fulminant endocarditis and disseminated infection caused by carbapenem-resistant Acinetobacter baumannii in a renal-pancreas transplant recipient

摘要

Acinetobacter baumannii is an important cause of healthcare-associated infections, and is particularly problematic among patients who undergo organ transplantation. We describe a case of fulminant sepsis caused by carbapenem-resistant A.baumannii harboring the bla(OXA-23) carbapenemase gene and belonging to international clone II. This isolate led to the death of a patient 6days after simultaneous kidney-pancreas transplantation. Autopsy findings revealed acute mitral valve endocarditis, myocarditis, splenic and renal emboli, peritonitis, and pneumonia. This case highlights the severe nature of certain A.baumannii infections and the vulnerability of transplanted patients to the increasingly intractable high-risk clones of multidrug-resistant organisms.