Expression of CBY and methylation of CBY at promoter region in human laryngeal squamous cell carcinoma

摘要

Aims and Background: Chibby (CBY), a beta-catenin binding partner, inhibits Wnt/beta-catenin-mediated transcriptional activation by competing with Tcf/Lef factors for beta-catenin binding and promoting the export of beta-catenin from nucleus to cytoplasm. The regulatory effect of CBY in this signaling pathway suggests its biological importance as a potential tumor suppressor gene. The purposes of this study were to determine whether the expression of CBY was downregulated in human laryngeal squamous cell carcinoma (LSCC) samples, the CpG sites of CBY at the promoter region were methylated in these tumor samples, and reduced expression of CBY was induced by methylation of CBY promoters.