Green Synthesis of Acetals/Ketals:Efficient Solvent-Free Process for the Carbonyl/Hydroxyl Group Protection Catalyzed by SBA-15 Materials

摘要

Acetals/ketals derived from the aldehydes/ ketones are easily prepared under solventless conditions.The process is heterogeneously catalysed using acid or basic mesoporous molecular sieves Al-SBA-15 and(Cs)Al-SBA-15.The catalytic procedure herein reported is applied to the preparation of the key intermediates for the synthesis of {3-[(2R,3R,4R,5R)-(2,3,4,5-tetrahydroxyhexane-1,6-diyl)]} di-1H-imidazole 2 with potential biomedical applications.