Transfusion-induced alloimmunization and platelet refractoriness in a mouse model: mechanisms and interventions

摘要

BACKGROUNDPlatelet (PLT) transfusions can be an essential therapy for patients with thrombocytopenia to maintain hemostasis. However, some patients become alloimmunized to antigens on PLTs (typically HLA), which can prevent efficacy of PLT transfusion due to antibody-mediated clearance. In extreme cases, patients with alloimmunization to multiple HLAs can become refractory to PLT transfusion, such that insufficient compatible PLT units can be found to meet transfusion needs.