The RHD(1227G > A) DEL-associated allele is the most prevalent DEL allele in Australian D- blood donors with C plus and/or E plus phenotypes

摘要

BackgroundRed blood cells (RBCs) with D antigen levels only detected by anti-D adsorption-elution and an antiglobulin test express a DEL phenotype. For two DEL types, including RHD(1227G>A), immunization of D- recipients has been reported. This study's aim was to measure the prevalence of DEL-associated RHD alleles in a cohort of Australian D- donors to develop a model to estimate alloimmunization risk.