CLEANLINESS AND DRAINABIL ITY AUK AMONG the most critical issues that manufacturers of products such as biopharmaceuticals and active pharmaceutical ingredients (APIs) must confront with their process lines.Producers face the prospect or losing millions of dollars each year because of improperly sloped process lines and entrapment in valves and fittings.Some products suit continuous processes.Typically,however,manufacturers must run multiple hatches and must clean between them using steam in place (SIP),dean in place (CIP) with a chemical agent,or both techniques.
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