Comprehensive analysis of RHD splicing transcripts reveals the molecular basis for the weak anti-D reactivity of D-el-red blood cells

摘要

Background: Of the Rh blood type, D-el is a rare variant that elicits the weakest anti-D reactivity. In this study, we revisit the genetic changes of D-el allele and characterise the RHD splicing transcripts to realise the molecular basis of D-el formation in the Taiwanese population.