The use of granulocyte colony stimulating factoR (G-CSF) (filgrastim) alone in the mobilization of stem cell in the autologous stem cell transplantation

摘要

Intensive chemotherapy followed by autologous stem cell transplantation (ASCT) in hematological malignancies, particularly in multiple myeloma (MM) and in relapsed or refractory lymphoma is currently the treatment of choice [1-3]. Mobilization of hematopoietic stem cell blood stem cells (HSCs) can be achieved either by the combination of chemotherapy plus growth factors [4,5] or by growth factors alone [6]. However, there is no consensus concerning the dose of growth factor alone that should be administered, with ranges varying from 5mug to 16mug/kg body weight [7].In this context, we report our experience in mobilization of HSCs using growth factor alone at the dose of 15mug/kg in MM, Hodgkin's lymphoma (HL) and non-Hodgkin lymphoma (NHL).