Report about the XVIIIth meeting of the Cancer Research Institute in its international cancer immunotherapy symposium series on October 6-8, 2010.

摘要

CD4 T cells play critical and diverse roles in controlling the immune response and therefore in immunotoxicology. Since the mid-1980s, researchers have identified a growing repertoire of CD4 T-cell subsets and have made great progress in elucidating their different functions and regulation. It is now known that, while some, such as Th1, Th2 and Th17, are involved in promoting immune response, others, such as regulatory T cells (Tregs), engage in immune suppression. The specific roles that these cells play in autoimmunity, infectious disease and cancer, however, remain unclear. Further characterizing CD4 T-cell types and defining their precise immunotoxic functions and relationships to disease states will present key challenges moving forward. The 2010 CRI Symposium with the title: "Multiple Functions of CD4 T Cells in Autoimmunity, Infectious Disease, and Cancer" will address these and other challenges facing basic research and clinical development in the field today.