Improvement of blood compatibility of artificial heart valves via titanium oxide film coated on low temperature isotropic carbon

摘要

Titanium oxide film was coated on the surface of low temperature isotropic carbon (LTI-carbon) by ion beam enhanced deposition (IBED) to improve the blood compatibility of the LTI-carbon mechanical heart valve. The prepared film was found to be polycrystalline with Ti{sup}(2+), Ti{sup}(3+) and Ti{sup}(4+) coexisting. This oxygen-lack n-type semiconductor film exhibits a better hemocompatibility than that of LTI-carbon in both in vitro and in vivo investigations. The reason is attributed to the surface energy and work function, which are two influencing factors on blood compatibility.