In vitro studies on the reaction rates of acrylamide with the key body-fluid thiols L-cysteine, glutathione, and captopril

摘要

The mechanisms of interactions of acrylamide with L-cysteine, glutathione and captopril were studied in vitro. Experimental second order rate constants calculated at 303 K were 0.34 +/- 0.02, 0.18 +/- 0.02, and 0.13 +/- 0.01 dm(3) mol(-1) s(-1) for L-cysteine, glutathione, and captopril, respectively, potentially involving inter- and intra-molecular H-bonding in the acrylamide-glutathione complex.