Engineering of a O-6-alkylguanine-DNA alkyltransferase chimera and repair of O-4-alkyl thymidine adducts and O-6-alkylene-2 '-deoxyguanosine cross-linked DNA

McManus Francis P.; Wilds Christopher J.

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Engineering of a O-6-alkylguanine-DNA alkyltransferase chimera and repair of O-4-alkyl thymidine adducts and O-6-alkylene-2 '-deoxyguanosine cross-linked DNA

机译：O-6-烷基鸟嘌呤-DNA烷基转移酶嵌合体的工程设计和O-4-烷基胸苷加合物和O-6-亚烷基-2'-脱氧鸟苷交联DNA的修复

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A soluble human O-6-alkylguanine-DNA alkyltransferase (hAGT) chimera was engineered containing the active site of OGT (residues 139-159) and an additional S134P mutation. The resulting hAGT chimera not only retained hAGT's ability to repair bulky O-6-alkylene-2'-deoxyguanosine interstrand cross-linked DNA damage but also displayed enhanced repair of various O-4-alkyl thymidine adducts.RI Wilds, Christopher/K-4012-2013OI Wilds, Christopher/0000-0002-0336-4753

机译：工程化的可溶性人O-6-烷基鸟嘌呤-DNA烷基转移酶（hAGT）嵌合体包含OGT的活性位点（残基139-159）和一个额外的S134P突变。产生的hAGT嵌合体不仅保留了hAGT修复庞大的O-6-亚烷基-2'-脱氧鸟苷链间交联的DNA损伤的能力，而且还增强了各种O-4-烷基胸苷加合物的修复能力.RI Wilds，Christopher / K- 4012-2013OI Wilds，Christopher / 0000-0002-0336-4753

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《Toxicology Research》 |2013年第3期|共5页
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McManus Francis P.; Wilds Christopher J.;
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1. Engineering of a O-6-alkylguanine-DNA alkyltransferase chimera and repair of O-4-alkyl thymidine adducts and O-6-alkylene-2 '-deoxyguanosine cross-linked DNA [J] . McManus Francis P., Wilds Christopher J. Toxicology Research . 2013,第3期

机译：O-6-烷基鸟嘌呤-DNA烷基转移酶嵌合体的工程设计和O-4-烷基胸苷加合物和O-6-亚烷基-2'-脱氧鸟苷交联DNA的修复
2. Repair of O-6-methylguanine adducts in human telomeric G-quadruplex DNA by O-6-alkylguanine-DNA alkyltransferase [J] . Hellman Lance M., Spear Tyler J., Koontz Colton J., Nucleic Acids Research . 2014,第15期

机译：通过O-6-烷基胍烷-DNA烷基转移酶修复人端粒型G-Quadrepled DNA中的O-6-甲基叶绿素加合物
3. Mass spectrometry based approach to study the kinetics of O6-alkylguanine DNA alkyltransferase-mediated repair of O6-pyridyloxobutyl-2'-deoxyguanosine adducts in DNA. [J] . Kotandeniya D, Murphy D, Seneviratne U, Chemical research in toxicology . 2011,第11期

机译：基于质谱的方法来研究O6-烷基鸟嘌呤DNA动力学的动力学烷基转移酶介导的DNA中O6-吡啶基氧代丁基2'-脱氧鸟苷加合物的修复。
4. Effect of Cr(VI)and bisphenol A on the formation of 8-hydroxy-2'deoxyguanosine DNA adduct from 2'-deoxyguanosine through a Fenton-like reaction [C] . Budiawan, E Kusumowardani, S Handayani International Symposium on Current Progress in Functional Materials . 2019

机译：Cr（VI）和双酚A通过FENTON样反应从2'-脱氧核苷酸形成8-羟基-2'deoxyguanneine DNA加合物的影响
5. Structural studies of the human DNA repair protein oxygen-6-alkylguanine-DNA alkyltransferase. [D] . Daniels, Douglas Stephen. 2001

机译：人类DNA修复蛋白氧-6-烷基鸟嘌呤-DNA烷基转移酶的结构研究。
6. Mass Spectrometry Based Approach to Study the Kinetics of O6-Alkylguanine DNA Alkyltransferase Mediated Repair of O6-pyridyloxobutyl-2′-deoxyguanosine Adducts in DNA [O] . Delshanee Kotandeniya, Dan Murphy, Uthpala Seneviratne, -1

机译：基于质谱法的方法来研究在DNa O6-pyridyloxobutyl脱氧鸟苷加合物的O6 - 烷基鸟嘌呤-DNa烷基介导的修复的动力学
7. Mass Spectrometry Based Approach to Study the Kinetics ofO6-Alkylguanine DNA Alkyltransferase-Mediated Repair ofO6-Pyridyloxobutyl-2′-deoxyguanosine Adducts in DNA [O] . Delshanee Kotandeniya, Dan Murphy, Uthpala Seneviratne, 2011

机译：基于质谱的基于方法研究O6-烷基胍DNA烷基转移酶介导的OF6-吡啶氧基-2'-脱氧核苷酸加合物的TMA6-烷基胍烷基烷基转移酶介导的DNA的动力学方法

Engineering of a O-6-alkylguanine-DNA alkyltransferase chimera and repair of O-4-alkyl thymidine adducts and O-6-alkylene-2 '-deoxyguanosine cross-linked DNA

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