首页> 外文期刊>Toxicology in vitro: an international journal published in association with BIBRA >Chromate-induced sulfur starvation and mRNA mistranslation in yeast are linked in a common mechanism of Cr toxicity.
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Chromate-induced sulfur starvation and mRNA mistranslation in yeast are linked in a common mechanism of Cr toxicity.

机译:铬引起的硫饥饿和酵母中的mRNA错译与铬毒性的常见机制有关。

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摘要

Toxicity of the environmental carcinogen chromate is known to involve sulfur starvation and also error-prone mRNA translation. Here we reconcile those facts using the yeast model. We demonstrate that: (i) cysteine and methionine starvation mimic Cr-induced translation errors, (ii) genetic suppression of S starvation suppresses Cr-induced mistranslation, and (iii) mistranslation requires cysteine and methionine biosynthesis. Therefore, Cr-induced S starvation is the cause of mRNA mistranslation. This establishes a single, novel pathway mediating the toxicity of chromate.
机译:已知环境致癌物铬酸盐的毒性涉及硫缺乏和易出错的mRNA翻译。在这里,我们使用酵母模型调和这些事实。我们证明:(i)半胱氨酸和蛋氨酸饥饿模拟Cr诱导的翻译错误,(ii)S饥饿的遗传抑制抑制了Cr诱导的翻译错误,并且(iii)错误翻译需要半胱氨酸和蛋氨酸的生物合成。因此,Cr诱导的S饥饿是mRNA错误翻译的原因。这建立了介导铬酸盐毒性的单一新颖途径。

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