Comment on: Effects of decabrominated diphenyl ether (PBDE 209) exposure at different developmental periods on synaptic plasticity in the dentate gyrus of adult rats in vivo.

摘要

Xing et al. (2009) exposed Wistar rats to decabromodi-phenyl ether (PBDE 209; CASRN 1163-19-5) during five developmental periods: pregnancy, lactation via mother's milk (indirect dosing), lactation via gavage (direct dosing), post-weaning (direct dosing), and prenatal to life (indirect dosing during gestation and lactation and direct dosing postweaning). All animals were evaluated on postnatal day 60. The authors reported that exposure during lactation was the most sensitive period for causing effects on postsynaptic cell excitability.