Monoclonal antibody-fluorescent probe conjugates for in vivo target-specific cancer imaging: Toward clinical translation

摘要

Fluorescence imaging, including endogenous fluorophores and exogenous fluorescent probes, has been used in clinical practice for many years. However, clinical applications in cancer remain limited and this seems to be a missed opportunity for improving patient care. Compared with current clinical imaging modalities, such as computed tomography, ultrasound, MRI, single-photon emission computed tomography and positron emission tomography, fluorescence imaging has the advantages of low cost, portability, no radiation exposure, high-resolution and real-time image acquisition, demonstrating promise in intraoperative and endoscopic cancer diagnosis.