The role of protein disulfide isomerase in the post-ligation phase of beta(3) integrin-dependent cell adhesion

Leader Avi; Mor-Cohen Ronit; Ram Ron; Sheptovitsky Vera; Seligsohn Uri; Rosenberg Nurit; Lahav Judith

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The role of protein disulfide isomerase in the post-ligation phase of beta(3) integrin-dependent cell adhesion

机译：蛋白质二硫键异构酶在β（3）整合素依赖性细胞黏附后连接阶段的作用

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Introduction: Protein disulfide isomerase (PDI) catalyzes disulfide bond exchange. It is crucial for integrin-mediated platelet adhesion and aggregation and disulfide bond exchange is necessary for alpha(IIb)beta(3) and alpha(v)beta(3) activation. However, the role of disulfide bond exchange and PDI in the post-ligation phase of alpha(IIb)beta(3) and alpha(v)beta(3) mediated cell adhesion has yet to be determined.

机译：简介：蛋白质二硫键异构酶（PDI）催化二硫键交换。这对于整合素介导的血小板粘附和聚集至关重要，而二硫键交换对于alpha（IIb）beta（3）和alpha（v）beta（3）激活是必需的。但是，二硫键交换和PDI在alpha（IIb）beta（3）和alpha（v）beta（3）介导的细胞粘附后连接阶段的作用尚未确定。

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来源
《Thrombosis Research: An International Journal on Vascular Obstruction, Hemorrhage and Hemostasis》 |2015年第6期|共7页
作者
Leader Avi; Mor-Cohen Ronit; Ram Ron; Sheptovitsky Vera; Seligsohn Uri; Rosenberg Nurit; Lahav Judith;
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正文语种 eng
中图分类神经病学;
关键词
Integrins; alpha(IIb)beta(3); alpha(v)beta(3); PDI; Disulfide bond; Cell adhesion;

机译：整联蛋白;alpha（IIb）beta（3）;alpha（v）beta（3）;PDI;二硫键;细胞粘附;

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1. The role of protein disulfide isomerase in the post-ligation phase of beta(3) integrin-dependent cell adhesion [J] . Leader Avi, Mor-Cohen Ronit, Ram Ron, Thrombosis Research: An International Journal on Vascular Obstruction, Hemorrhage and Hemostasis . 2015,第6期

机译：蛋白质二硫键异构酶在β（3）整合素依赖性细胞黏附后连接阶段的作用
2. Role of the 52 KDa thioredoxin protein disulfide isomerase of Toxoplasma gondii during infection to human cells [J] . Moncada Diego, Arenas Aylan, Acosta Alejandro, Experimental parasitology . 2016,第Null期

机译：弓形虫52 KDa硫氧还蛋白蛋白二硫键异构酶在感染人细胞中的作用
3. Protein disulfide isomerase increases in myocardial endothelial cells in mice exposed to chronic hypoxia: a stimulatory role in angiogenesis. [J] . Tian F, Zhou X, Wikstrom J, American Journal of Physiology . 2009,第3aPta2期

机译：暴露于慢性缺氧的小鼠中心肌内皮细胞的蛋白质二硫化物异构酶增加：血管生成中的刺激作用。
4. Overexpression of protein disulfide isomerase-like protein in a mouse leukemia L1210 cell lineselected for resistance to 4-methyl-5-amino-l-formylisoquinoline thiosemicarbazone, aribonucleotide reductase inhibitor [C] . Taria R. Crenshaw, Joseph G. Cory International Symposium on Regulation of Enzyme Activity and Synthesis in Normal and Neoplastic Tissues . 2003

机译：在小鼠白血病L1210细胞中过表达蛋白二硫化物异构酶样蛋白，其含有对抗4-甲基-5-氨基-1-甲醛异喹啉硫代喹啉硫代喹啉硫代喹啉的，因此
5. The role of integrin-dependent cell matrix adhesion in muscle development. [D] . Jani, Klodiana. 2009

机译：整合素依赖性细胞基质粘附在肌肉发育中的作用。
6. Nucleotide sequence of a full-length cDNA clone encoding a mouse cellular thyroid hormone binding protein (p55) that is homologous to protein disulfide isomerase and the beta-subunit of prolyl-4-hydroxylase. [O] . Q H Gong, T Fukuda, C Parkison, 1988

机译：全长cDNA克隆的核苷酸序列其编码与蛋白质二硫键异构酶和脯氨酰-4-羟化酶的β亚基同源的小鼠细胞甲状腺激素结合蛋白（p55）。
7. Protein disulfide isomerase mediates integrin-dependent adhesion [O] . Lahav J., Gofer-Dadosh N., Luboshitz J., 2000

机译：蛋白质二硫键异构酶介导整合素依赖性粘附

The role of protein disulfide isomerase in the post-ligation phase of beta(3) integrin-dependent cell adhesion

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