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C-C chemokine receptor 2 expression by circulating monocytes influences atherosclerosis in patients on chronic hemodialysis.

机译:循环血液单核细胞的C-C趋化因子受体2表达影响慢性血液透析患者的动脉粥样硬化。

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摘要

Mortality from cardiovascular or cerebrovascular disease due to atherosclerosis is increased in patients on chronic hemodialysis. Monocyte chemoattractant protein-1 and its receptor, C-C chemokine receptor 2, play an important role in recruiting monocytes to atherosclerotic lesions. The relationship between atherosclerosis in hemodialysis patients and C-C chemokine receptor 2 expression is unknown. Fifty-six patients on chronic hemodialysis and 27 age- and sex-matched controls were enrolled. Serum levels of monocyte chemoattractant protein-1 and expression of C-C chemokine receptor 2 by circulating monocytes were determined. Atherosclerosis was evaluated from the carotid intima-media thickness and cardio-ankle vascular index. Serum levels of monocyte chemoattractant protein-1 and expression of C-C chemokine receptor 2 by monocytes were significantly higher in the hemodialysis patients than the controls. Multiple regression analysis showed a positive correlation between receptor expression and both indexes of atherosclerosis. C-C chemokine receptor 2 expression by circulating monocytes influences atherosclerosis in patients on chronic hemodialysis.
机译:进行慢性血液透析的患者因动脉粥样硬化而导致的心血管或脑血管疾病死亡率增加。单核细胞趋化蛋白-1及其受体C-C趋化因子受体2在募集单核细胞至动脉粥样硬化病变中起重要作用。血液透析患者的动脉粥样硬化与C-C趋化因子受体2表达之间的关系尚不清楚。纳入了56例接受慢性血液透析的患者以及27例年龄和性别匹配的对照。通过循环单核细胞测定血清单核细胞趋化蛋白-1的水平和C-C趋化因子受体2的表达。从颈动脉内膜中层厚度和心踝血管指数评估动脉粥样硬化。血液透析患者的单核细胞血清单核细胞趋化蛋白-1水平和C-C趋化因子受体2的表达明显高于对照组。多元回归分析显示受体表达与动脉粥样硬化的两个指标之间呈正相关。循环血液单核细胞的C-C趋化因子受体2表达影响慢性血液透析患者的动脉粥样硬化。

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