Polymorphisms in the Annexin A5 gene influence circulating Annexin A5 levels in healthy controls

摘要

Annexin A5 (ANXA5), a Ca~(2+)- and phospholipid-binding protein of the annexin family, has strong anticoagulant and antithrombotic properties as well as antiinflammatory features, both in vitro and in vivo [1-5]. Its exact physiological function, however, has not been fully understood. Circulating ANXA5 levels are low in healthy individuals (0 to 5 ng/mL) [6]. Elevated plasma ANXA5 levels reported in patients with acute myocardial infarction, severe trauma [7,8] and sickle cell disease [9] are shown to reflect the severity of cell damage. Reduced plasma ANXA5 levels are associated with the presence and extent of atherosclerotic plaques [10] as well as recurrent pregnancy loss [11].