Factor VIIa-antithrombin complexes plasma levels in cancer patients with and without thrombosis

摘要

Active cancer is one of the most well known causes of an acquired prothrombotic state [1 ]. No global test that can be used routinely to monitor the development of hypercoagulability in these patients is known. Recently our group described elevated plasma levels of the complex between activated factor VII and antithrombin (FVIIa-AT) in subjects, both adults and children, who had had a previous throm-botic event [2,3]. Due to the higher risk of recurrence we consider these subjects to have a hypercoagulable condition and speculated on a possible use of increased plasma levels of FVIIa-AT complex as a marker of a hypercoagulable state.