Defective annexin A5 crystallization: a mechanism for pregnancy losses in the antiphospholipid syndrome.

摘要

We have accumulated a significant body of evidence that support the hypothesis that aPL antibody-mediated disruption of annexin A5 crystallization is a mechanism for RSPL in the APS. Further investigation of the functions of the annexins in placental physiology and disease are likely to be productive areas for future research.