Using Fluorescence Polarization Immunoassay for Determination of Erythrocyte Methotrexate Polyglutamates, a Quick and Easy Test?

den Boer Ethan; Koch Birgit C. P.; Huisman Ruud; de Jonge Robert

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Using Fluorescence Polarization Immunoassay for Determination of Erythrocyte Methotrexate Polyglutamates, a Quick and Easy Test?

机译：使用荧光偏振免疫测定法测定快速简便的红细胞氨甲蝶呤多谷氨酸吗？

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Background: The folate antagonist methotrexate (MTX) is the anchor drug in the treatment of rheumatoid arthritis. The therapeutic effects of MTX are attributed to the intracellular levels of MTX, present in the cell as polyglutamates (MTX-PGs). We aimed to validate an immunoassay for the measurement of MTX-PG in erythrocytes.

机译：背景：叶酸拮抗剂甲氨蝶呤（MTX）是治疗类风湿关节炎的主要药物。 MTX的治疗作用归因于MTX的细胞内水平，其以聚谷氨酸盐（MTX-PG）的形式存在于细胞中。我们旨在验证一种用于测定红细胞中MTX-PG的免疫测定方法。

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《Therapeutic Drug Monitoring》 |2014年第6期|共5页
作者
den Boer Ethan; Koch Birgit C. P.; Huisman Ruud; de Jonge Robert;
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正文语种 eng
中图分类生药学（天然药物学）;
关键词
methotrexate; methotrexate polyglutamates; erythrocytes; rheumatoid arthritis; FPIA;

机译：甲氨蝶呤;甲氨蝶呤聚谷氨酸盐;红细胞;类风湿关节炎;FPIA;

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1. Using Fluorescence Polarization Immunoassay for Determination of Erythrocyte Methotrexate Polyglutamates, a Quick and Easy Test? [J] . den Boer Ethan, Koch Birgit C. P., Huisman Ruud, Therapeutic Drug Monitoring . 2014,第6期

机译：使用荧光偏振免疫测定法测定快速简便的红细胞氨甲蝶呤多谷氨酸吗？
2. Erythrocyte Methotrexate-polyglutamate Assay Using Fluorescence Polarization Immunoassay Technique: Application to the Monitoring of Patients with Rheumatoid Arthritis [J] . Sachie INOUE, Masayuki HASHIGUCHI, Shinichi KAWAI, 藥學雜誌 . 2009,第8期

机译：荧光偏振免疫测定技术测定红细胞甲氨蝶呤-聚谷氨酸：在类风湿关节炎患者监测中的应用
3. Application of fluorescence polarization immunoassay for determination of methotrexate-polyglutamates in rheumatoid arthritis patients. [J] . Hayashi H, Fujimaki C, Tsuboi S, The Tohoku Journal of Experimental Medicine . 2008,第1期

机译：荧光偏振免疫测定法在类风湿关节炎患者中测定甲氨蝶呤-聚谷氨酸盐的应用。
4. Fluorescence Polarization Immunoassay in the Detection of Brucella [C] . Peng Li, Tao Geng, HaiBin Wu International Conference on Civil Engineering and Building Materials . 2011

机译：荧光偏振免疫测定在褐土检测中
5. Development of High-Throughput Fluorescence Polarization Immunoassay System by a Fluorescence Polarization Imaging Technique [D] . 若尾, 摂 2019

机译：荧光偏振成像技术开发高通量荧光偏振免疫分析系统
6. Determination of blood sirolimus concentrations in liver and kidney transplant recipients using the Innofluor® fluorescence polarization immunoassay: Comparison with the microparticle enzyme immunoassay and high-performance liquid chromatography-ultraviolet method [O] . Lorena Bouzas, Jesús Hermida, J Carlos Tutor 2009

机译：使用Innofluor®荧光偏振免疫测定法测定肝肾移植受者的西罗莫司浓度：与微粒酶免疫测定法和高效液相色谱-紫外线法的比较
7. Evaluation of High Performance Liquid Chromatography for Determination of Methotrexate in Human Serum. Comparison with Fluorescence Polarization Immunoassay and Application for Osteosarcoma Patients. [O] . RYOICHI MINAGAWA, YUKIKO WATANABE, DENJIRO KAJI, 1994

机译：高效液相色谱法测定人血清中甲氨蝶呤的高效液相色谱评价。荧光偏振免疫测定与骨肉瘤患者的应用比较。

Using Fluorescence Polarization Immunoassay for Determination of Erythrocyte Methotrexate Polyglutamates, a Quick and Easy Test?

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