CYP2B6 516G > T (rs3745274) and Smoking Status Are Associated With Efavirenz Plasma Concentration in a Serbian Cohort of HIV Patients

Olagunju Adeniyi; Siccardi Marco; Amara Alieu; Jevtovic Djordje; Kusic Jovana; Owen Andrew; Dragovic Gordana

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CYP2B6 516G > T (rs3745274) and Smoking Status Are Associated With Efavirenz Plasma Concentration in a Serbian Cohort of HIV Patients

机译：CYP2B6 516G> T（rs3745274）和吸烟状态与HIV病人的塞尔维亚人群中的依夫韦伦血浆浓度相关

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Background: Genetic factors have been associated with efavirenz (EFV) plasma concentrations in different populations. In this study, we investigated the effects of CYP2B6 516G>T (rs3745274), CYP2B6 c.485-18C>T (rs4803419), CAR c.540C>T (rs2307424), CAR c.152-1089T>C (rs3003596), and smoking status in a cohort of Serbian patients with HIV.

机译：背景：遗传因素已与不同人群中的依非韦伦（EFV）血浆浓度相关。在这项研究中，我们研究了CYP2B6 516G> T（rs3745274），CYP2B6 c.485-18C> T（rs4803419），CAR c.540C> T（rs2307424），CAR c.152-1089T> C（rs3003596）的影响以及一组塞尔维亚艾滋病毒患者的吸烟状况。

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《Therapeutic Drug Monitoring》 |2014年第6期|共5页
作者
Olagunju Adeniyi; Siccardi Marco; Amara Alieu; Jevtovic Djordje; Kusic Jovana; Owen Andrew; Dragovic Gordana;
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正文语种 eng
中图分类生药学（天然药物学）;
关键词
efavirenz; pharmacogenetics; CYP2B6 516G gt; T; rs3745274; constitutive androstane receptor;

机译：依非韦伦;药物遗传学;CYP2B6 516G T;rs3745274;组成型雄烷受体;

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1. CYP2B6 516G > T (rs3745274) and Smoking Status Are Associated With Efavirenz Plasma Concentration in a Serbian Cohort of HIV Patients [J] . Olagunju Adeniyi, Siccardi Marco, Amara Alieu, Therapeutic Drug Monitoring . 2014,第6期

机译：CYP2B6 516G> T（rs3745274）和吸烟状态与HIV病人的塞尔维亚人群中的依夫韦伦血浆浓度相关
2. Haplotype structure of CYP2B6 and association with plasma efavirenz concentrations in a Chilean HIV cohort [J] . Daniel F. Carr, Charles J. L. la Porte, Munir Pirmohamed, Journal of Antimicrobial Chemotherapy . 2010,第9期

机译：智利HIV队列中CYP2B6的单倍型结构及其与血浆依非韦伦浓度的关系
3. Haplotype structure of CYP2B6 and association with plasma efavirenz concentrations in a Chilean HIV cohort. [J] . Carr DF, la Porte CJ, Pirmohamed M, The Journal of Antimicrobial Chemotherapy . 2010,第9期

机译：智利HIV人群中CYP2B6的单倍型结构及其与血浆依法韦仑浓度的相关性。
4. Efavirenz Plasma Concentrations -Is Gender Important? [C] . SA Pereira, RM Corte Real, T Branco International AIDS Conference . 2004

机译：efavirenz等离子体浓度 - 性别重要吗？
5. The relationship of physician trust and statin adherence to age and HIV/AIDS status in older persons living with HIV/AIDS and cardiovascular disease: A secondary data analysis from the Veterans Aging Cohort Study. [D] . Petrovic, Kimberly. 2012

机译：患有艾滋病毒/艾滋病和心血管疾病的老年人的医师信任和他汀类药物依从性与年龄和艾滋病毒/艾滋病状况的关系：退伍军人老龄化队列研究的次要数据分析。
6. Presence of the CYP2B6 516G T polymorphism increased plasma Efavirenz concentrations and early neuropsychiatric side effects in South African HIV-infected patients [O] . Verena Gounden, Chantal van Niekerk, Tracy Snyman, 2010

机译：南非HIV感染患者存在CYP2B6 516G T多态性血浆依法韦仑浓度升高和早期神经精神病学副作用
7. Presence of the CYP2B6 516G>T polymorphism and increased plasma Efavirenz concentrations in South African HIV infected patients [O] . Gounden Verena 2011

机译：南非HIV感染患者中CYP2B6 516G> T多态性的存在和血浆依法韦仑浓度升高

CYP2B6 516G > T (rs3745274) and Smoking Status Are Associated With Efavirenz Plasma Concentration in a Serbian Cohort of HIV Patients

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