Critical differences of acute phase proteins in canine serum samples

摘要

The critical difference values for acute phase proteins in canine serum samples were established on a week-to-week basis. Blood samples from 11 apparently clinically healthy dogs were collected once weekly for five consecutive weeks. For each protein the total variance of analytical results was divided into intraindividual (S-Intra(2)), interindividual variance (S-Inter(2)), and analytical variance (S-Analytical(2)). The critical difference (d(K)) was then calculated as d(k) = 2root2(S-Intra(2) + S-Analytical(2)). The critical difference values were 1.95 g/L for haptoglobin, 4.85 mg/L for C-reactive protein, and 0.0 16 DeltaAbs/min for ceruloplasmin.