Feline injection-site sarcoma Recurrence, tumour grading and surgical margin status evaluated using the three-dimensional histological technique

摘要

The three-dimensional histology technique is used in human medicine for the evaluation of complete lateral and deep surgical margins In this study the technique was applied to 48 excised feline injection-site sarcoma specimens The predictive value of the histological margin status and tumour grading on local recurrence was investigated In 32/48 cases the margins were non-infiltrated whilst in the remaining 16 cases they were infiltrated Overall 6/32 (19%) tumours with non-infiltrated margins and 11/16 (69%) with infiltrated margins recurred Tumours with infiltrated margins recurred about 10 times more frequently compared to tumours with non-infiltrated margins (P = 0 0011) No statistically significant correlation was observed between grading and recurrence The assessment of margin status using the 3D histology technique showed a good predictivity for post-surgical tumour recurrence Extensive application of the 3D histology technique is recommended to standardise the evaluation of histological margins and to allow comparison between results from different laboratories