Concentrations of clindamycin hydrochloride in homogenates of normal dog skin when administered at two oral dosage regimens

摘要

Background: Clindamycin is frequently used for the treatment of bacterial pyoderma. Objective: To compare the pharmacokinetics of clindamycin in whole skin homogenates of normal dogs when administered orally at two dosage regimens (5.5mg/kg BW, twice daily and 11mg/kg BW, once daily). Animals and Methods: Skin biopsies were obtained from six laboratory beagles before, 3, 6 and 12h after the first and the fifth dose of clindamycin at the former regimen, as well as before, 3, 6, 12 and 24h after the first and third dose at the latter regimen. Tissue was homogenized and clindamycin concentrations were measured by reverse-phase high-performance liquid chromatography coupled with mass spectrometry. Results were analyzed using Student's t-test at a level of significance of 0.05. Results: Maximal concentration and area under the concentrationtime curve, but not their relevant dose-normalized values, were higher at the dosage regimen of 11mg/kg BW, once daily than at 5.5mg/kg BW twice daily. Conclusions: The pharmacokinetic profile of clindamycin is at least equal, if not better, when this antimicrobial is administered at 11mg/kg BW, once daily.