The use of cDNA microarrays to investigate changes in gene expression in the involuting bovine mammary gland

摘要

The molecular mechanisms and pathways involved in involution of the udder and which coordinate and regulate the processes of cell death and proliferation after weaning/cessation of milking in ruminants, are poorly understood. The aim of this study wasto use cDNA microarray analysis to identify genes and pathways involved in involution of the bovine mammary gland. Ultimately, because this process underpins lactation traits such as persistency and mammary responses to milking frequency (Stelwagen, 2001; Vetharaniam et al., 2003), this information may allow the development of novel strategies for improving milk production especially in the later stages of lactation.