Serotonin, presynaptic 5-HT receptors and synaptic plasticity in the developing cerebellum.

摘要

In a recent article in The Journal of Physiology, Oostland and colleagues (2011), present evidence for strong serotonergic regulation of synaptic plasticity at parallel fibre presynaptic terminals on Purkinje cells during early postnatal development. Specifically, the authors demonstrate the essential role of presynaptic ligand-gated ion channel type 3 serotonin receptors (5-HT_3 receptors) at this synapse. Indeed, the parallel fibre-Purkinje cell (PF-PC) synapse displayed no apparent synaptic plasticity in slices from 1-week-old mice, as measured using a paired-pulse protocol.