How to shut down Ca2+-induced Ca2+ release?

摘要

After each heart beat, the cardiac muscle needs to relax promptly to allow refilling of the ventricles with blood during the diastole. Thus, the Ca~(2+) transients activating muscle contraction are required to terminate rapidly and reliably. For the activation of cardiac muscle contraction, Ca~(2+)-induced Ca~(2+) release (CICR) is the primary Ca~(2+) signal amplifier.