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外文期刊>The Journal of the Acoustical Society of America
>Locus of generation for the 2f_1 - f_2 vs 2f_2 - f_1 distortion-product otoacoustic emissions in normal-hearing humans revealed by suppression tuning, onset latencies, and amplitude correlations
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Locus of generation for the 2f_1 - f_2 vs 2f_2 - f_1 distortion-product otoacoustic emissions in normal-hearing humans revealed by suppression tuning, onset latencies, and amplitude correlations
The present study used distortion-product otoacoustic emission (DPOAE) suppression tuning curves (STCs), DPOAE onset latencies (OLs), and DPOAE amplitude correlations to investigate the locus of generation of the 2f_1 - f_2 DPOAE versus the 2f_2 - f_1 DPOAE in humans. The results of the tuning study revealed that, for the 2f_1 - f_2 DPOAE, the tips of the STCs tuned consistently below the geometric-mean (GM) frequency of the primary tones. In contrast, for the 2f_2 - f_1 DPOAE, STCs tuned above the GM of the primaries, with 50% of the tip frequencies at, or above, the 2f_2 - f_1 frequency place. When the average ratio of the 2f_2 - f_1 to the 2f_1 - f_2 tip frequencies was computed, a factor of 1.44 provided an estimate of the frequency shift needed to align the two DPOAE generation sites. Other results showed that OLs for the 2f_2 - f_1 DPOAE were uniformly shorter than those for the 2f_1 - f_2, with difference at the low frequencies amounting to as much as 6-7 ms. Further, for both DPOAEs, curves describing latency decreases as a function of increasing GM frequencies were best fit by power functions. Shifting the GM frequency producing the 2f_2 - f_1 DPOAE by a factor of 1.6 caused the latency distributions for both DPOAEs to overlap thus resulting in a single function that described cochlear delay as a function of GM frequency. Finally, for each GM frequency in the DP-gram, sliding correlations from 108 normal ears were performed on both DPOAEs by holding the primaries producing the 2f_1 - f_2 DPOAE constant, while all 2f_2 - f_1 DPOAE amplitudes were successively correlated with the 2f_1 - f_2 amplitudes. This procedure demonstrated that, for a given GM frequency producing the 2f_1 - f_2, the correlations between the two DPOAEs peaked when the primaries of the 2f_2 - f_1 were at a GM frequency that positioned the 2f_2 - f_1 frequency place near the GM of the primaries that produced the 2f_1 - f_2 DPOAE. As a whole, the above findings strongly suggest that the 2f_2 - f_1 DPOAE in humans is generated basal to the primary-tone place on the basilar membrane.
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