Mechanical models for the self-organizationof tubular patterns

摘要

Organogenesis, such as long tubule self-organization, requireslong-range coordination of cell mechanics to arrange cellpositions and to remodel the extracellular matrix. While thecurrent mainstream in the field of tissue morphogenesisfocuses primarily on genetics and chemical signaling, theinfluence of cell mechanics on the programming of patterningcues in tissue morphogenesis has not been adequatelyaddressed. Here, we review experimental evidence andpropose quantitative mechanical models by which cells cancreate tubular patterns.