Anti-PD1 antibody: Aa new approach to treatment of lymphomas

摘要

Irnmunomodulation of the T-cell response can be mediated by many mechanisms including soluble factors such as IL-10 or TGFp immunoregulatory cell subsets such as regulatory T cells or follicular helper T cells, and surface receptors such as PD1 (programmed cell death 1, also known as PDCD1), LAG3, CD244, TIM3 (also known as HAVCR2), CTLA4, or CD160. PD1, a member of the B7 receptor family, is engaged by two ligands (PD-L1 [also known as CD274] and PD-L2 [also known as PDCD1LG2]) that are expressed by numerous cell types. This receptor-ligand axis was shown to be of utmost importance for T-cell exhaustion, a state of dysfunction encountered in cases of chronic infection or cancer. Downstream targets of PD1 engagement by its ligands-down regulation of T-cell receptor and PIK3CA-AKT1 pathways and direct interaction with transcription factors such as BATF-partly explain its inhibitory properties.