HowAIPexerts itstumour-suppressor action remains to be determined. It is involved in mediating toxic effects of dioxins and is also known to interact with a phosphodiesterase, finking A1P to cyclic AMP, which has a strong role in the generation of pituitary adenomas.Julian Davis (Manchester Infirmary, UK), says: "What is interesting...is that they have found a predisposing gene with their strategy. In terms of pituitary disease, [ think it will lead to further screening for other genes and their products".
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