Copper moves across membranes during angiogenesis.

摘要

During angiogenesis, a large proportion of the cellular copper is transferred to the tips of nascent endothelial cell filopodia and across the cell membrane (Proc Natl Acad Sci USA 2007; 104: 2247-52). "This particular finding was quite surprising. The dramatic changes we saw in which some 80-90% of copper is relocalised implies that there may be a larger dynamic element in such a regulation of protein activity and localisation", says author David Glesne (Argonne National Laboratory, Argonne, IL, USA).