Familial breast cancer: the first linkage.

摘要

The identification of a new gene that affects cancer susceptibility is now almost a daily event, so the report in Science in 1990 from a team led by Mary-Claire King1 might now seem rather mundane. However, the importance of this paper should not be underestimated: it was the turning point after which it could no longer be denied that genetic variation had an effect on breast cancer risk