Erratum: Consensus statements for the use of administrative health data in rheumatic disease research and surveillance (Journal of Rheumatology (2013) 40 (66-73))

摘要

As Dr. Ranganathan stated, it would be interesting to know whether MTX pharmacogenetic associations are comparable between children with JIA and adults with RA. Therefore, we also have investigated transporter gene polymorphisms in a cohort of 387 adult patients with RA. The following adverse events were analyzed after 3 months of therapy: GI events (diarrhea, vomiting, and sickness or abdominal pain) and malaise (fatigue, dizziness, headache, and sleeplessness or feeling not well). GI adverse events were observed in 43% of the patients and malaise in 45%. In univariate logistic regression analysis, we found only 1 significant association: the ABCB1 rslO45642 polymorphism was associated with malaise (OR 2.57, 95% CI 1.59-4.15, p < 0.001).