Genetic variation in PCLO is associated with prefrontal cortex expression and bipolar disorder.

摘要

There is no shortage of findings in studies of postmortem brains of patients with psychiatric disorders (1). Evidence that these findings are related to the pathophysiology and/or etiology of major mental illnesses has been far less common. Confounds of treatment, substance abuse, and postmortem artifacts that affect RNA and protein degradation are unfortunately the rule rather than the exception (2). The advent of agnostic, hypothesis-blind approaches, such as microchip array expression technology, have the potential to exacerbate this problem insofar as these studies generate data on thousands of genes in a single experiment.