Drug shortages--a critical challenge for the generic-drug market.

摘要

While the oncology community has been focusing much of its attention on the remarkable activity and enviable science related to the discovery of targeted drugs, the importance of standard cytotoxic therapeutics has suddenly become apparent, owing to shortages of the common workhorses of cancer treat- ment - methotrexate, leucovorin, 5-fluorouracil, cytosine arabino-side, vincristine, etoposide, the an-thracyclines, paclitaxel, cisplatin, and others.