Treating childhood leukemia without cranial irradiation.

摘要

to the editor: An association between throm-botic events and the use of asparaginase in children with ALL is well known. Asparaginase decreases the plasma level of antithrombin, which is an inhibitor of coagulation and thrombin regulation.1 Children with standard-risk and high-risk ALL in the study reported on by Pui and colleagues received a higher than usual dose of asparaginase, which could account for the increased incidence of thrombosis. In how many of these children did cortical vein thrombosis develop