Dengue and Yellow Fever - Challenges for the Development and Use of Vaccines

摘要

Dengue is an important hu-man viral disease transmitted by insects. Although nearly half the world's population is at risk for infection and as many as 100 million cases occur annually,1 we have no antiviral drugs to treat it and no vaccines to prevent it. A closely related but much more lethal mosquito-borne virus, yellow fever, used to be one of the great scourges among humans. Although yellow fever is now largely controlled by vaccination, many regions are susceptible to a reemergence if the disease is introduced by travelers,#