Genetic polymorphism of the PCR-based locus HLA-DQA1 in Jordanians

摘要

Genotype and allele frequencies for the PCR-based locus HLA-DQA1 were determined in a randomly selected sample population consisting of 163 unrelated Jordanians. Genotype 4.1-4.1 was the most common with a frequency of 0.1779, followed by genotype 1.1-4.1 occurring at a frequency of 0.1104. HLA-DQA1 locus genotype distribution in Jordanians was in agreement with the expectations of the Hardy-Weinberg equilibrium. The most common HLA-DQA1 allele in Jordnians was allele 4.1. The least common allele was 4.2/4.3. Distribution of the HLA-DQA1 locus in Jordanians is similar to those in other Arab populations as revealed by G test statistic P values. Based on these findings, the calculated P_I value of the HLA-DQA1 locus in Jordanians was 0.08200. These data could be useful for forensic analysis and paternity testing procedures in the Jordanians society.