Oral Sildenafil in the Treatment of Erectile Dysfunction I. Goldstein, T.F. Lue, H. Padma-Nathan, R.C. Rosen, W.D. Steers, and P.A. Wicker, for the Sildenafil Study Group

摘要

By providing the first evidence of an orally effective pharmaceutical agent for human erectile dysfunction (ED), this article changed the landscape of the treatment of ED. This change is impossible to fully appreciate for clinicians who began medical training after 1998. Prior to this publication and the subsequent global introduction of sildenafil into clinical practice, the only treatments available for ED were penile injections, implants, and vacuum devices, and these treatments were only available through specialists. More importantly, there was great shame associated with ED, and few men sought medical attention, as ED was thought to be primarily of psychogenic origin.